Negative regulation of epidermis development

Across TCGA cell cohorts, RNA activity of the Negative regulation of epidermis development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UVSSA, STX16, and ST3GAL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UVSSA grouped by Negative regulation of epidermis development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UVSSA →	-1.886	-1.551	.004	.003	3	5
UPPER_AERODIGESTIVE_TRACT	STX16 →	-1.216	-1.180	.001	.001	3	5
LIVER	ST3GAL1 →	+2.328	+1.479	.007	.004	3	4
UPPER_AERODIGESTIVE_TRACT	MYSM1 →	-2.138	-1.497	<.001	.001	3	4
PANCREAS	ZNF25 →	-0.694	-1.463	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	COG6 →	-0.833	-1.323	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UVSSA by Negative regulation of epidermis development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →