Negative regulation of epidermis development

Across TCGA cell cohorts, RNA activity of the Negative regulation of epidermis development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF234, KIT, and ROS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF234 grouped by Negative regulation of epidermis development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF234 →	+0.185	+0.161	<.001	<.001	3	5
LUNG_SCLC	KIT →	+0.143	+0.186	.001	<.001	3	4
BREAST	ROS1 →	-0.142	-0.094	.003	.007	3	4
BLOOD_Lymphoma	TPTE2P2 →	+0.247	+0.244	<.001	.004	3	4
BLOOD_Lymphoma	BARX2 →	-0.302	-0.170	<.001	.006	3	4
BLOOD_Lymphoma	KLF6 →	+0.502	+0.207	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF234 by Negative regulation of epidermis development activity — PANCREAS

Explore this box plot interactively →