Regulation of osteoclast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN22, TNFRSF14, and JAML, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast differentiation activity versus PTPN22 in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPN22 →	+0.693	+0.482	<.001	<.001	3	7
GBM	TNFRSF14 →	+0.720	+0.502	<.001	.004	3	6
LSCC	JAML →	+0.737	+0.651	.001	.005	3	6
GBM	IL18R1 →	+1.143	+0.702	<.001	<.001	3	6
LSCC	LRPPRC →	-0.493	-0.679	.001	<.001	3	6
GBM	SAMSN1 →	+0.804	+0.537	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045670 vs PTPN22 — GBM

Explore this scatter interactively →