Regulation of osteoclast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoclast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGD3, CNIH2, and ADA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast differentiation activity versus TIGD3 in LUNG_NSCLC_LUAD (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TIGD3 →	-0.452	-0.714	.006	.001	3	4
LUNG_NSCLC_LUAD	CNIH2 →	-0.765	-0.516	.003	.006	3	4
BLOOD_Leukemia	ADA2 →	-1.964	-0.854	.007	<.001	3	3
SOFT_TISSUE	SLC35A2 →	-0.740	-1.226	.004	.008	3	3
BREAST	CORO1C →	+1.042	+1.051	<.001	.002	2	4
BREAST	TBC1D30 →	-1.270	-1.013	.008	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045670 vs TIGD3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →