Positive regulation of osteoblast differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF350, LTBP2, and ZNF112, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF350 grouped by Positive regulation of osteoblast differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF350 →	+0.776	+0.410	.008	.003	3	6
LIVER	LTBP2 →	+2.526	+0.473	.009	.002	3	5
LIVER	ZNF112 →	+0.765	+0.484	.001	<.001	3	5
LUNG_SCLC	CARD10 →	+2.646	+0.205	<.001	.006	3	4
KIDNEY	YIPF4 →	+0.667	+0.307	<.001	.001	3	4
SKIN	ZNF585A →	+1.206	+0.188	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF350 by Positive regulation of osteoblast differentiation activity — BONE

Explore this box plot interactively →