Positive regulation of osteoblast differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF140, SAE1, and STK31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of osteoblast differentiation activity versus ZNF140 in LARGE_INTESTINE (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF140 →	-1.707	-1.082	.004	.004	3	5
OVARY	SAE1 →	+0.961	+1.312	<.001	<.001	3	5
PANCREAS	STK31 →	-1.102	-1.146	<.001	.002	3	4
LUNG_SCLC	CACFD1 →	-1.259	-0.886	.002	.006	3	4
LUNG_SCLC	PIP5KL1 →	-1.053	-1.235	.002	<.001	3	4
LUNG_SCLC	EBF4 →	-1.567	-0.652	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045669 vs ZNF140 — LARGE_INTESTINE

Explore this scatter interactively →