Regulation of osteoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, BCL2, and EFCAB7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGB1 grouped by Regulation of osteoblast differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITGB1 →	+1.641	+0.245	.003	.001	2	7
LUNG_SCLC	BCL2 →	-2.416	-0.232	.008	.001	3	5
KIDNEY	EFCAB7 →	-0.585	-0.259	<.001	<.001	3	5
LUNG_SCLC	SDSL →	+2.626	+0.259	<.001	<.001	3	5
LIVER	ZNF410 →	+0.830	+0.236	<.001	.002	3	5
LUNG_NSCLC_LUAD	ABL2 →	+1.354	+0.142	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGB1 by Regulation of osteoblast differentiation activity — LIVER

Explore this box plot interactively →