Positive regulation of neuron differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, KRI1, and LAMA4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron differentiation activity versus VCAN in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VCAN →	+0.484	+0.020	.007	.001	3	6
LSCC	KRI1 →	-0.433	-0.052	<.001	<.001	3	6
BRCA	LAMA4 →	+0.607	+0.025	<.001	.001	2	7
CCRCC	VCL_S579 →	+0.629	+0.037	<.001	.001	3	6
OV	COL3A1 →	+0.956	+0.046	<.001	.001	3	6
UCEC	CYGB →	+0.578	+0.047	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045666 vs VCAN — COAD

Explore this scatter interactively →