Positive regulation of neuron differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STXBP4, C2orf68, and RMND5A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STXBP4 grouped by Positive regulation of neuron differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	STXBP4 →	+0.823	+0.964	.005	.008	3	4
LUNG_NSCLC_LUAD	C2orf68 →	+0.619	+0.973	.001	<.001	3	4
SKIN	RMND5A →	+0.483	+1.150	.008	<.001	3	3
BREAST	TIMM44 →	+0.483	+0.777	.005	.005	3	3
OVARY	PTN →	-1.417	-0.856	.003	.005	3	3
OVARY	NMNAT1 →	-0.696	-0.739	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STXBP4 by Positive regulation of neuron differentiation activity — BLOOD_Leukemia

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