Positive regulation of neuron differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF3C, SNX2, and HMCES, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron differentiation activity versus KIF3C in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIF3C →	+0.970	+0.687	.007	.005	3	4
LUNG_NSCLC_LUSC	SNX2 →	+0.823	+1.454	.007	.002	3	4
KIDNEY	HMCES →	+0.852	+0.352	.008	.006	3	3
BLOOD_Myeloma	VWCE →	-1.520	-0.442	.005	.001	3	3
BLOOD_Myeloma	GPR137 →	+0.825	+0.297	.006	.002	3	3
SOFT_TISSUE	EXTL1 →	-3.684	-1.982	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045666 vs KIF3C — BLOOD_Lymphoma

Explore this scatter interactively →