Negative regulation of neuron differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8, TRIM2, and NCF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron differentiation activity versus TNFAIP8 in GBM (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFAIP8 →	-0.660	-0.054	<.001	<.001	3	6
HNSC	TRIM2 →	+0.692	+0.058	<.001	<.001	3	6
GBM	NCF2 →	-0.563	-0.050	.001	.002	3	6
UCEC	TMF1 →	-0.248	-0.059	.005	.003	3	5
HNSC	ZMYND11 →	+0.368	+0.069	<.001	<.001	3	5
HNSC	ADNP →	+0.351	+0.072	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045665 vs TNFAIP8 — GBM

Explore this scatter interactively →