Negative regulation of neuron differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP9_S113, SOX9, and SAMHD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron differentiation activity versus ARHGAP9_S113 in OV (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP9_S113 →	-0.737	-1.052	.002	<.001	3	4
LUAD	SOX9 →	+1.665	+0.793	<.001	<.001	3	3
UCEC	SAMHD1 →	-0.498	-0.248	.002	.005	3	3
CCRCC	SMPD2 →	-1.138	-1.364	<.001	<.001	3	3
UCEC	TTC28_S2398 →	+0.755	+0.267	.001	.007	2	4
OV	USP34_T3381 →	+0.983	+1.392	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045665 vs ARHGAP9_S113 — OV

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