Negative regulation of neuron differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB3, CFL2, and ACSS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERBB3 grouped by Negative regulation of neuron differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ERBB3 →	+1.405	+0.872	.008	.003	3	4
STOMACH	CFL2 →	-1.989	-0.752	.001	.002	3	4
LUNG_NSCLC_LUSC	ACSS2 →	+1.380	+0.276	.002	.001	3	3
CNS	CTSV →	+1.834	+0.894	.001	.001	2	4
LUNG_NSCLC_LUSC	LIMK1 →	+1.210	+0.312	.007	<.001	3	3
BLOOD_Leukemia	PDE3B →	+1.954	+0.938	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERBB3 by Negative regulation of neuron differentiation activity — CNS

Explore this box plot interactively →