Regulation of neuron differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND2D, LAMC1, and MYO1G, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron differentiation activity versus DENND2D in UCEC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DENND2D →	-0.250	-0.043	.002	<.001	3	7
CCRCC	LAMC1 →	+0.610	+0.049	<.001	<.001	3	7
GBM	MYO1G →	-0.568	-0.039	.001	<.001	3	7
CCRCC	PARP14 →	-0.404	-0.041	<.001	<.001	3	7
UCEC	POSTN →	+1.099	+0.055	<.001	<.001	3	7
LSCC	IKBKG →	-0.250	-0.027	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045664 vs DENND2D — UCEC

Explore this scatter interactively →