Regulation of neuron differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, RUNX1, and B3GNT5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron differentiation activity versus TGFBI in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TGFBI →	+4.316	+0.249	<.001	.002	3	6
LUNG_NSCLC_LUAD	RUNX1 →	+1.387	+0.188	.002	.007	3	6
SOFT_TISSUE	B3GNT5 →	+3.074	+0.273	.001	.009	3	6
BREAST	SLFN5 →	+1.210	+0.174	.006	<.001	3	6
OVARY	HIVEP2 →	+1.328	+0.212	.002	.007	2	6
OVARY	RTN4 →	+1.293	+0.298	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045664 vs TGFBI — OVARY

Explore this scatter interactively →