Positive regulation of myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AGO1, FBLN5, and RPL27A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myoblast differentiation activity versus AGO1 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AGO1 →	+0.239	+0.050	<.001	.007	3	7
CCRCC	FBLN5 →	+0.773	+0.033	.005	.004	3	7
GBM	RPL27A →	-0.222	-0.037	.005	<.001	3	6
GBM	RPL5 →	-0.173	-0.050	.001	<.001	3	6
GBM	SYAP1_S313 →	-0.355	-0.043	.008	.003	3	6
HNSC	RPL26 →	-0.332	-0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045663 vs AGO1 — HNSC

Explore this scatter interactively →