Positive regulation of myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myoblast differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN4, ZFP2, and KCNK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN4 grouped by Positive regulation of myoblast differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTPN4 →	+0.186	+0.099	.002	<.001	3	5
LUNG_SCLC	ZFP2 →	+0.235	+0.109	.009	.005	3	4
SOFT_TISSUE	KCNK3 →	+0.133	+0.081	<.001	.005	3	4
BLOOD_Myeloma	ADAM17 →	-0.292	-0.107	.003	.007	3	4
STOMACH	SMPD2 →	+0.118	+0.140	.004	.005	3	4
OVARY	FAM32A →	-0.346	-0.108	.008	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN4 by Positive regulation of myoblast differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →