Positive regulation of myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27L, ADGRV1, and AGPAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myoblast differentiation activity versus RPS27L in URINARY_TRACT (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RPS27L →	-1.420	-1.549	.005	.004	3	6
LUNG_SCLC	ADGRV1 →	+2.346	+1.271	<.001	.002	3	6
SKIN	AGPAT1 →	-1.309	-1.497	.006	<.001	3	5
OESOPHAGUS	IGSF9 →	+1.651	+1.348	.004	.008	3	5
LUNG_NSCLC_LUSC	TAF9 →	-0.972	-2.153	.001	<.001	3	5
OVARY	AVPI1 →	-1.523	-1.741	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045663 vs RPS27L — URINARY_TRACT

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