Negative regulation of myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MICAL3_S1371, GEMIN5, and HSPA9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myoblast differentiation activity versus MICAL3_S1371 in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MICAL3_S1371 →	+0.463	+0.043	.001	.008	3	6
CCRCC	GEMIN5 →	-0.166	-0.037	.002	.004	3	5
OV	HSPA9 →	-0.396	-0.039	<.001	<.001	3	5
BRCA	VSNL1 →	+0.824	+0.044	<.001	<.001	3	5
OV	CNRIP1 →	+0.575	+0.038	.003	.001	3	5
PDAC	COL5A1 →	+0.636	+0.040	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045662 vs MICAL3_S1371 — UCEC

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