Negative regulation of myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN5, NEK9, and ZNF491, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myoblast differentiation activity versus TSPAN5 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TSPAN5 →	+0.483	+0.647	<.001	<.001	3	4
HNSC	NEK9 →	+0.331	+0.665	.004	.001	2	5
GBM	ZNF491 →	+0.501	+0.589	.003	<.001	3	4
GBM	ZNF781 →	+0.857	+0.606	.001	.003	3	4
CCRCC	ZNF671 →	+0.609	+0.577	.002	.001	3	4
GBM	PARP11-AS1 →	+0.407	+0.604	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045662 vs TSPAN5 — CCRCC

Explore this scatter interactively →