Regulation of myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of myoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RBM47, EPB41L2, and CLINT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast differentiation activity versus RBM47 in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBM47 →	-0.690	-0.040	<.001	<.001	3	7
PDAC	EPB41L2 →	+0.263	+0.026	.003	.003	3	6
UCEC	CLINT1 →	-0.180	-0.031	.001	.006	3	6
HNSC	DBN1 →	+0.333	+0.053	.002	.004	3	5
PDAC	GSN →	+0.488	+0.030	.003	<.001	3	5
OV	RTN1 →	+0.490	+0.032	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045661 vs RBM47 — GBM

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