Regulation of myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO17, IFI6, and TRPC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO17 grouped by Regulation of myoblast differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FBXO17 →	-3.541	-0.345	.002	.007	3	5
LUNG_NSCLC_LUSC	IFI6 →	-2.851	-0.325	.005	.001	3	5
LUNG_NSCLC_LUSC	TRPC1 →	-1.691	-0.278	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CDS1 →	+2.040	+0.245	<.001	.001	3	5
LUNG_SCLC	C6orf132 →	+2.000	+0.371	<.001	<.001	3	5
LUNG_NSCLC_LUSC	DENND1C →	+2.587	+0.291	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO17 by Regulation of myoblast differentiation activity — STOMACH

Explore this box plot interactively →