Regulation of myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RND3, CCL25, and PHB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RND3 grouped by Regulation of myoblast differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RND3 →	-0.300	-0.093	.008	.005	2	5
OVARY	CCL25 →	-0.231	-0.054	.006	.001	3	4
OVARY	PHB →	+0.234	+0.036	<.001	.006	2	5
OVARY	SCN9A →	-0.213	-0.048	.005	<.001	2	5
UPPER_AERODIGESTIVE_TRACT	TBC1D13 →	+0.134	+0.095	.001	.004	3	4
SOFT_TISSUE	ABCC8 →	-0.170	-0.083	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RND3 by Regulation of myoblast differentiation activity — SOFT_TISSUE

Explore this box plot interactively →