Regulation of myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-ND1, RAPGEF5, and MYO5C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast differentiation activity versus MT-ND1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MT-ND1 →	+1.413	+1.421	<.001	.003	3	6
LUNG_NSCLC_LUSC	RAPGEF5 →	+1.931	+2.065	.001	<.001	3	6
LUNG_NSCLC_LUAD	MYO5C →	+1.418	+1.106	.005	<.001	3	5
STOMACH	OXSM →	-0.802	-1.759	.006	<.001	3	5
SOFT_TISSUE	ZNF223 →	+1.066	+1.060	.001	.005	3	5
OESOPHAGUS	ACOX3 →	-0.627	-1.692	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045661 vs MT-ND1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →