Negative regulation of monocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of monocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18, FNBP1, and SH3BGRL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte differentiation activity versus PPP1R18 in GBM (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R18 →	+0.468	+0.112	<.001	<.001	3	8
HNSC	FNBP1 →	+0.378	+0.076	<.001	<.001	3	8
LSCC	SH3BGRL →	+0.503	+0.119	<.001	<.001	3	7
LSCC	SLC25A5 →	-0.426	-0.114	<.001	<.001	3	7
GBM	TBC1D2B →	+0.388	+0.101	<.001	<.001	3	7
GBM	VIM →	+0.578	+0.099	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045656 vs PPP1R18 — GBM

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