Negative regulation of monocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of monocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK6, MYC, and HOXA7, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monocyte differentiation activity versus CDK6 in BLOOD_Myeloma (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDK6 →	+2.026	+0.295	<.001	<.001	3	12
LUNG_SCLC	MYC →	+4.861	+1.604	<.001	<.001	3	12
BLOOD_Leukemia	HOXA7 →	-2.016	-0.179	<.001	<.001	2	10
SOFT_TISSUE	PUS7 →	+0.767	+0.161	<.001	<.001	3	8
SOFT_TISSUE	GEMIN5 →	+0.529	+0.155	.007	.003	2	9
SOFT_TISSUE	TTLL12 →	+0.869	+0.168	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045656 vs CDK6 — BLOOD_Myeloma

Explore this scatter interactively →