Regulation of monocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of monocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP2, ST8SIA4, and LAX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monocyte differentiation activity versus GIMAP2 in HNSC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP2 →	+0.807	+0.202	.002	.002	2	6
HNSC	ST8SIA4 →	+0.561	+0.250	.003	<.001	3	5
HNSC	LAX1 →	+0.710	+0.149	.003	<.001	3	5
HNSC	GBP4 →	+1.063	+0.210	<.001	<.001	3	5
HNSC	GVINP1 →	+0.843	+0.211	.002	.002	3	5
LSCC	ADAMTS7 →	-0.576	-0.270	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045655 vs GIMAP2 — HNSC

Explore this scatter interactively →