Regulation of monocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of monocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCH, TMEM248, and SPAG17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monocyte differentiation activity versus PRKCH in URINARY_TRACT (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRKCH →	+3.603	+0.478	<.001	.004	3	5
OESOPHAGUS	TMEM248 →	-0.796	-0.358	.007	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SPAG17 →	-0.719	-0.323	<.001	.004	2	5
LARGE_INTESTINE	NFX1 →	-0.567	-0.412	<.001	<.001	3	4
OESOPHAGUS	FBXO48 →	-0.731	-0.345	<.001	.003	3	4
BLOOD_Leukemia	SNX9 →	-1.715	-0.336	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045655 vs PRKCH — URINARY_TRACT

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