Positive regulation of megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATA2, MTURN, and FAXDC2, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of megakaryocyte differentiation activity versus GATA2 in CHOL (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	GATA2 →	+1.876	+0.081	.005	.001	1	25
SCLC	MTURN →	+1.475	+0.175	.001	<.001	2	24
TGCT	FAXDC2 →	+1.014	+0.064	<.001	<.001	3	22
LIHC	TESC →	+1.917	+0.029	<.001	<.001	3	21
CHOL	GATA2-AS1 →	+1.982	+0.064	.009	.006	1	22
UVM	PSMA3-AS1 →	+0.803	+0.058	.003	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045654 vs GATA2 — CHOL

Explore this scatter interactively →