Positive regulation of megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID4A, PAXIP1-DT, and LRRC37B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of megakaryocyte differentiation activity versus ARID4A in COAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ARID4A →	+0.251	+0.192	.004	.003	3	4
BRCA	PAXIP1-DT →	+0.410	+0.140	.001	.002	3	4
BRCA	LRRC37B →	+0.336	+0.131	<.001	.004	3	4
LUAD	KIAA1191 →	+0.320	+0.180	.002	<.001	3	3
UCEC	TESC →	+1.259	+0.138	.004	.004	2	4
COAD	UBR1 →	+0.393	+0.240	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045654 vs ARID4A — COAD

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