Positive regulation of megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SVIL, PROSER1, and PPFIA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SVIL grouped by Positive regulation of megakaryocyte differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SVIL →	-1.323	-1.128	<.001	.008	3	4
BLOOD_Myeloma	PROSER1 →	+0.752	+0.394	.004	.002	2	4
SOFT_TISSUE	PPFIA1 →	+0.669	+1.131	.009	.004	3	3
BLOOD_Leukemia	TRIM66 →	+0.969	+1.385	<.001	<.001	3	3
BLOOD_Leukemia	FOSL1 →	+1.454	+0.806	.001	.004	3	3
BLOOD_Leukemia	SNX11 →	+0.605	+0.942	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SVIL by Positive regulation of megakaryocyte differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →