Positive regulation of megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM201, PITHD1, and PPP1R8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of megakaryocyte differentiation activity versus TMEM201 in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM201 →	+0.798	+0.257	<.001	<.001	3	5
LUNG_SCLC	PITHD1 →	+0.629	+0.271	.002	<.001	3	5
BLOOD_Leukemia	PPP1R8 →	+0.471	+0.141	<.001	.007	3	5
LUNG_SCLC	REEP4 →	-0.438	-0.198	.008	.006	3	4
BLOOD_Leukemia	SMARCD1 →	+0.988	+0.179	<.001	<.001	3	4
BREAST	SAP30 →	+1.360	+0.270	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045654 vs TMEM201 — LUNG_SCLC

Explore this scatter interactively →