Regulation of megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of megakaryocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, PHLDB1, and SFXN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of megakaryocyte differentiation activity versus CNRIP1 in COAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CNRIP1 →	+0.378	+0.022	.004	.008	3	5
LSCC	PHLDB1 →	+0.341	+0.050	.004	<.001	3	5
LSCC	SFXN1 →	-0.319	-0.048	.003	.003	3	5
UCEC	YME1L1 →	-0.229	-0.051	.008	.005	3	5
UCEC	CDC16_S560 →	-0.270	-0.090	.009	.004	3	5
LSCC	ISYNA1 →	+0.423	+0.042	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045652 vs CNRIP1 — COAD

Explore this scatter interactively →