Regulation of megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCYT1A, DPP4-DT, and STAMBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of megakaryocyte differentiation activity versus PCYT1A in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PCYT1A →	-0.467	-0.137	.007	.002	3	4
UCEC	DPP4-DT →	+0.464	+0.114	.008	.005	3	3
HNSC	STAMBP →	-0.349	-0.165	.002	<.001	3	3
GBM	MIR924HG →	+0.952	+0.259	<.001	<.001	3	3
BRCA	RNU2-30P →	+0.122	+0.234	.006	.004	3	3
LSCC	NAB1 →	-0.297	-0.101	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045652 vs PCYT1A — LSCC

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