Regulation of megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PJA1, EDEM2, and CCN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PJA1 grouped by Regulation of megakaryocyte differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PJA1 →	+1.508	+0.310	.002	.003	3	4
LUNG_NSCLC_LUAD	EDEM2 →	-0.609	-0.253	.001	.002	3	4
BLOOD_Leukemia	CCN4 →	-0.055	-0.221	.007	<.001	3	4
BREAST	JTB →	+0.720	+0.206	.002	.001	3	4
BREAST	EVPL →	+1.768	+0.205	.002	.003	3	4
BLOOD_Leukemia	TFAM →	+0.816	+0.222	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PJA1 by Regulation of megakaryocyte differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →