Negative regulation of macrophage differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATA2, INHBA, and LTBP2, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage differentiation activity versus GATA2 in CHOL (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	GATA2 →	+1.398	+0.094	<.001	<.001	3	24
CHOL	INHBA →	+1.780	+0.081	<.001	<.001	3	22
CHOL	LTBP2 →	+1.608	+0.067	<.001	<.001	3	21
UCEC	ZBTB46 →	+0.690	+0.060	<.001	<.001	3	21
SCLC	TNFRSF4 →	+1.143	+0.234	<.001	<.001	3	21
CHOL	PTGIR →	+0.807	+0.066	.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045650 vs GATA2 — CHOL

Explore this scatter interactively →