Negative regulation of macrophage differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GFPT2, RCN3, and SH3PXD2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage differentiation activity versus GFPT2 in GBM (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GFPT2 →	+0.619	+0.059	<.001	<.001	3	7
GBM	RCN3 →	+0.628	+0.061	<.001	<.001	3	7
CCRCC	SH3PXD2B →	+0.299	+0.063	<.001	<.001	3	7
CCRCC	FAP →	+0.683	+0.079	.006	.001	3	7
PDAC	SERPINE1 →	+0.796	+0.059	.005	.006	3	6
GBM	SULF1 →	+1.006	+0.072	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045650 vs GFPT2 — GBM

Explore this scatter interactively →