Negative regulation of macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF841, ZNF506, and UBXN7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF841 grouped by Negative regulation of macrophage differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF841 →	+0.884	+0.923	.005	.007	3	4
LUNG_NSCLC_LUAD	ZNF506 →	+1.211	+0.921	<.001	.001	3	4
LUNG_SCLC	UBXN7 →	+1.181	+0.361	.001	.007	3	4
BLOOD_Leukemia	RPP40 →	-0.906	-0.863	.006	.003	3	4
KIDNEY	UBXN2A →	+0.794	+1.199	.004	.002	3	4
BLOOD_Myeloma	VEGFB →	+0.875	+0.357	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF841 by Negative regulation of macrophage differentiation activity — KIDNEY

Explore this box plot interactively →