Negative regulation of macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage differentiation pathway is significantly associated with the drug response of multiple features, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are ZM447439, XAV939, and Ibrutinib, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZM447439 grouped by Negative regulation of macrophage differentiation-low versus -high activity in KIDNEY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZM447439 →	-1.540	-0.127	.033	.036	3	2
KIDNEY	XAV939 →	-1.016	-0.168	.033	.028	3	2
SKIN	Ibrutinib →	-1.509	-1.779	.021	.022	3	2
KIDNEY	Doramapimod →	-1.185	-0.147	.009	.045	3	2
KIDNEY	RO-3306 →	-1.099	-0.169	.035	.010	3	2
SKIN	Gefitinib →	-1.280	-1.834	.008	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZM447439 by Negative regulation of macrophage differentiation activity — KIDNEY

Explore this box plot interactively →