Regulation of macrophage differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TUBB6, C1R, and EMILIN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage differentiation activity versus TUBB6 in UCEC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBB6 →	+0.500	+0.081	<.001	<.001	3	9
OV	C1R →	+0.531	+0.049	.004	<.001	3	9
BRCA	EMILIN1 →	+0.414	+0.041	.001	<.001	3	9
LSCC	FKBP10 →	+0.611	+0.069	<.001	<.001	3	9
GBM	P3H1 →	+0.781	+0.096	<.001	<.001	3	9
OV	ACTN1 →	+0.411	+0.045	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045649 vs TUBB6 — UCEC

Explore this scatter interactively →