Regulation of macrophage differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX41, ADAMTS4, and ZNF483, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage differentiation activity versus TEX41 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TEX41 →	+0.624	+0.175	.002	.001	3	5
LUAD	ADAMTS4 →	+0.749	+0.167	.003	<.001	3	4
LUAD	ZNF483 →	-0.543	-0.155	<.001	.002	3	4
UCEC	CALHM5 →	+0.495	+0.212	<.001	.003	3	4
GBM	SYNGR1 →	-0.687	-0.253	.003	.001	3	3
GBM	CRYM →	-0.763	-0.220	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045649 vs TEX41 — LUAD

Explore this scatter interactively →