Regulation of macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF862, NOP16, and CELF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF862 grouped by Regulation of macrophage differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF862 →	+1.530	+1.219	<.001	.001	3	5
KIDNEY	NOP16 →	-0.677	-1.234	.005	.001	3	4
OVARY	CELF4 →	+0.776	+0.849	.001	.008	2	4
BLOOD_Lymphoma	CDK8 →	-1.060	-1.569	.004	.008	2	4
BLOOD_Lymphoma	TRPC1 →	-1.230	-1.622	.002	.007	3	3
SKIN	SLC1A3 →	+1.804	+1.323	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF862 by Regulation of macrophage differentiation activity — OVARY

Explore this box plot interactively →