Positive regulation of erythrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of erythrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC2, LAMA5, and LBH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of erythrocyte differentiation activity versus SDC2 in SKIN (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SDC2 →	+2.640	+0.811	<.001	<.001	3	4
OESOPHAGUS	LAMA5 →	-1.336	-0.758	.009	.004	3	4
OESOPHAGUS	LBH →	-2.603	-1.037	<.001	<.001	3	4
OESOPHAGUS	PABPC1 →	+1.032	+1.276	.006	<.001	3	4
BLOOD_Leukemia	CPQ →	+1.643	+0.185	<.001	<.001	3	4
BLOOD_Leukemia	NTHL1 →	-0.526	-0.147	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045648 vs SDC2 — SKIN

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