Negative regulation of erythrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of erythrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, DIP2C, and PCBP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP1B1 grouped by Negative regulation of erythrocyte differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CYP1B1 →	+1.801	+0.241	.003	.001	3	4
LUNG_NSCLC_LUSC	DIP2C →	+1.751	+0.159	<.001	.002	3	3
LUNG_NSCLC_LUSC	PCBP4 →	+1.501	+0.148	.004	.006	3	3
BLOOD_Leukemia	APBB3 →	+1.464	+0.740	.001	.009	3	3
BLOOD_Lymphoma	CCDC96 →	-0.431	-0.371	.007	.005	2	4
PANCREAS	FAM83D →	-1.027	-0.393	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP1B1 by Negative regulation of erythrocyte differentiation activity — OESOPHAGUS

Explore this box plot interactively →