Negative regulation of erythrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of erythrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMO, TMEM129, and DNLZ, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of erythrocyte differentiation activity versus TRMO in BLOOD_Leukemia (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRMO →	-0.908	-0.145	<.001	.002	3	2
BLOOD_Leukemia	TMEM129 →	+0.508	+0.162	.002	.001	3	2
LUNG_SCLC	DNLZ →	-1.086	-0.213	.003	.006	3	2
LUNG_SCLC	ZNF317 →	-0.780	-0.154	<.001	.006	3	2
BLOOD_Leukemia	SRRD →	-1.090	-0.111	<.001	.009	3	1
BLOOD_Leukemia	L3MBTL2 →	-0.455	-0.119	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045647 vs TRMO — BLOOD_Leukemia

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