Regulation of erythrocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of erythrocyte differentiation pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 47 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of erythrocyte differentiation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

UVM, LGG, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.368	0.779	.003	64	view →
LGG	OS	Tertile	All	0.314	0.569	<.001	46	view →
HNSC	DFS	Quartile	III,IV	0.775	0.501	<.001	46	view →
SKCM	OS	Tertile	II,III,IV	0.523	0.311	.005	36	view →
LIHC	OS	Quartile	II,III,IV	0.380	0.665	.008	20	view →
ACC	DFS	Median	All	0.142	0.661	<.001	16	view →
KIRP	DFS	Quartile	All	0.349	0.841	.002	16	view →
UCEC	DFS	Quartile	All	0.774	0.874	.014	16	view →
CHOL	DFS	Tertile	II,III,IV	0.130	0.548	.004	15	view →
READ	OS	Median	II,III,IV	0.830	0.396	.007	14	view →
COAD	DFS	Tertile	All	0.579	0.725	.018	12	view →
BLCA	OS	Quartile	All	0.676	0.298	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0045646–UVM (OS)

Open the UVM breakdown →