Positive regulation of myeloid cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBP1, CD180, and LILRB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid cell differentiation activity versus ZBP1 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZBP1 →	+0.751	+0.174	<.001	<.001	3	5
PDAC	CD180 →	+0.476	+0.152	<.001	.002	3	5
PDAC	LILRB1 →	+0.335	+0.148	.004	.004	3	5
BRCA	CD48 →	+0.683	+0.171	.008	.006	3	5
PDAC	NCKAP1L →	+0.399	+0.147	.001	.005	3	5
PDAC	TTC24 →	+0.190	+0.139	.003	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045639 vs ZBP1 — LSCC

Explore this scatter interactively →