Positive regulation of myeloid cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNGR2, RUNX3, and RSPH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid cell differentiation activity versus SYNGR2 in SKIN (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SYNGR2 →	-1.149	-0.712	.003	.002	3	4
BONE	RUNX3 →	+2.512	+0.267	.004	.001	3	3
LUNG_NSCLC_LUAD	RSPH1 →	-0.804	-0.436	.002	.009	3	3
PANCREAS	NR3C1 →	+0.859	+0.263	.007	.009	2	4
LIVER	COIL →	-1.099	-0.195	.007	.006	3	3
BREAST	ATP6V1G1 →	-0.542	-0.297	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045639 vs SYNGR2 — SKIN

Explore this scatter interactively →