Regulation of myeloid cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myeloid cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLIG3, MICU3, and AP3M2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OLIG3 grouped by Regulation of myeloid cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OLIG3 →	-0.239	-0.171	.006	.005	3	6
OESOPHAGUS	MICU3 →	-0.265	-0.155	<.001	.002	3	5
PANCREAS	AP3M2 →	+0.182	+0.154	.006	.001	3	5
LUNG_NSCLC_LUAD	KDELR3 →	-0.099	-0.098	.004	.008	3	4
LUNG_NSCLC_LUAD	RNF11 →	-0.087	-0.104	.003	<.001	3	4
LUNG_NSCLC_LUAD	CRK →	+0.191	+0.086	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OLIG3 by Regulation of myeloid cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →