Positive regulation of T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD53, EVI2B, and CYTH4, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 2 cell differentiation activity versus CD53 in SKCM (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CD53 →	+2.143	+0.084	<.001	<.001	3	31
SARC	EVI2B →	+1.896	+0.096	<.001	<.001	3	31
SARC	CYTH4 →	+1.843	+0.097	<.001	<.001	3	30
UCS	IL4I1 →	+2.465	+0.078	<.001	<.001	3	30
LAML	MS4A4A →	+2.226	+0.143	<.001	<.001	3	30
SARC	IL10RA →	+1.895	+0.093	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045630 vs CD53 — SKCM

Explore this scatter interactively →